Fundraising & Diligence

Engineering the Logic Behind Deep Tech Deals

How to make scientific risk legible, translate evidence into leverage, and shape the negotiation before the term sheet arrives

Apr 23 • Giulia Spano, PhD

How to Actually Price Deep Tech by Value

The choice that makes or breaks the return architecture.

Mar 12 • Nicola Marchese, MD

Underwriting Advanced Materials for AI Data Center Cooling | The Scenarionist

An analysis combining five case studies, thermoeconomics, and practical reasoning to navigate risk and build durable advantage

Feb 26

Reverse Diligence: How Two Next-Gen Compute Players Challenge the GPU Monoculture with Photonic and Analog AI Chips

A reverse DD analysis of two real-world scale-ups on architectural moats, foundry dependence, and scaling non-GPU compute for latency- and…

Dec 11, 2025 • Giulia Spano, PhD

100 Episodes, 10 Powerful Questions: A Special Edition of Deep Tech Catalyst

Reaching this milestone felt like the right moment to do something simple but demanding: to distill what we’ve learned.

Nov 28, 2025 • Nicola Marchese, MD

When Markets Derisk, Materials Matter

How to identify the companies with real collateral, sticky demand, and strategic leverage when capital leaves narrative-driven markets.

Nov 4, 2025

Beyond Dilution: Venture Debt & Revenue Sharing for Deep Tech Ventures

How New Models pairing equity with venture debt and revenue sharing bridge the lab-to-market gap for capital-intensive Deep Tech.

Oct 17, 2025 • Giulia Spano, PhD

Pre-Revenue Valuation in Deep Tech: How to Price What Doesn’t Exist Yet — Chapter 2

Valuation in Action: Deep Tech Startups and Real-World Case Studies

Sep 23, 2025 • Nicola Marchese, MD and Giulia Spano, PhD

Pre-Revenue Valuation in Deep Tech: How to Price What Doesn’t Exist Yet — Chapter 1

How do you build a pre-revenue valuation in deep tech, where ARR doesn’t exist and the “market” still needs to be educated?

Sep 20, 2025 • Giulia Spano, PhD and Nicola Marchese, MD

The Room Where Deep Tech Deals Are Decided...

Electrons, interconnects, and the leverage that actually closes a deep-tech round.

Sep 18, 2025 • Giulia Spano, PhD

AI ≠ SaaS: the Metrics Reset.

Why Continuous Calibration/Continuous Development (CC/CD) Redefines Scalability and Risk in AI Startups.

Aug 28, 2025 • Giulia Spano, PhD

Deep Tech Investment Secrets: What Top VCs Do Differently - Part 2

Designing scarcity, mapping risk, and replacing TAM theater with real buyer-backed growth models.

Aug 21, 2025

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