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The Scenarionist - Deep Tech Startups & Venture Capital

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AI ≠ SaaS: the Metrics Reset.
Why Continuous Calibration/Continuous Development (CC/CD) Redefines Scalability and Risk in AI Startups.
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Giulia Spano, PhD
The Silent Gold Rush of AI-Powered Lab Automation
Five startups, one rumor: the lab is going fully autonomous.
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Giulia Spano, PhD
 and 
Nicola Marchese, MD
10 Truths No One Tells You About Building a Deep Tech Team
You Don’t Scale Science. You Scale People.
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Giulia Spano, PhD
💸 $405M Robot Brains; $463M EV Anodes; $275M GPU Credit; $313M Gene Therapy; $230M Corporate Security; $100M Nuclear for AI | Capital…
The Week’s State of Deep Tech Capital: who’s Raising, who’s Betting, and why.
 • 
Giulia Spano, PhD
🤖Frontier AI Capex;⚡Firm Power Near Load; 🛰️Edge Analytics in Orbit; 🔋Grid Batteries Energized; ⚛️ Advanced Fission Trains Up & more…
Weekly Intelligence on Deep Tech Startups and Venture Capital.

DeepTech Briefing

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🤖Frontier AI Capex;⚡Firm Power Near Load; 🛰️Edge Analytics in Orbit; 🔋Grid Batteries Energized; ⚛️ Advanced Fission Trains Up & more…
Weekly Intelligence on Deep Tech Startups and Venture Capital.
Why Are US VCs Writing AI Term Sheets Far From Sand Hill Road? | Deep Tech Briefing #74
Weekly Intelligence on Deep Tech Startups and Venture Capital.
 • 
Giulia Spano, PhD
Why GPT-5’s “Underwhelm” Is Bullish for Deep Tech & more... | Deep Tech Briefing #73
Weekly Intelligence on Deep Tech Startups and Venture Capital.
 • 
Giulia Spano, PhD
📈Strategic Dual-Use IPO; ⚛️ First Fusion Power to Grid;⚡Virtual Power Plants Scale; 🔋First Grid-Scale Sodium-Ion Battery; 🚀 NASA Backs…
Weekly Independent Intelligence on Deep Tech Startups and Venture Capital.
 • 
Giulia Spano, PhD

DeepTech Catalyst

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20:56
AgTech From Lab to Scale: Moats, Markets, and Strategy | Deep Tech Catalyst
Watch now | A chat with Ana Ward, Venture Capitalist @ Yanmar Ventures
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Nicola Marchese, MD
What VCs Look For in Early‑Stage Diagnostics | Deep Tech Catalyst
Watch now | A chat with Tom Miller, Founder and Managing Partner @ GreyBird Ventures
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Nicola Marchese, MD
30:50
Private Equity Meets Mining Tech: How to Scale Innovation From Site to Strategic Exits | Deep Tech Catalyst
Watch now | A chat with Charles Gillies, Managing Director @ RCF Innovation
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Nicola Marchese, MD
28:19
Forestry x Carbon Credits: Building Investable Models at the Frontier of Nature Tech | Deep Tech Catalyst
Watch now (25 mins) | A chat with Chloë Payne, Principal @ Ponderosa Ventures
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Nicola Marchese, MD
24:46
Crop Protection From Lab to Scalable Ventures: Strategy, Regulation, and Market Fit | Deep Tech Catalyst
Watch now | A chat with Sara Olson, Senior Director of Crop Science Venture Investments at Leaps by Bayer
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Nicola Marchese, MD
31:41

Insights

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Deep Tech Investment Secrets: What Top VCs Do Differently - Part 2
Designing scarcity, mapping risk, and replacing TAM theater with real buyer-backed growth models.
Deep Tech Investment Secrets: What Top VCs Do Differently - Part 1
Strategic patterns used by leading deep tech investors to get better deals, faster access, and lower downstream risk.
The Power Law of Matter: Why Advanced Materials are Eating Digital Margins
From SaaS Logic to Commodity Logic. From advanced materials in photonics to fusion energy — the real profit pools are moving back into the atomic layer.
When Niche Beats Scale: How Top-Tier Deep Tech Startups Thrive in Unsexy Markets
Power Laws and the Hidden Edge of Niche Dominance: 3 Real-World Case Studies
 • 
Giulia Spano, PhD
Reverse Diligence: How Three Advanced Energy Materials Companies Beat the Scaling Bottleneck
Amprius, Nexeon & Enovix: A reverse DD analysis of three real-world scale-ups on moats, capital discipline, and scaling advanced materials for…
Pre-Revenue Valuation in Deep Tech: How to Price What Doesn’t Exist Yet — Part 2
Valuation in Action: Deep Tech Startups and Real-World Case Studies
Pre-Revenue Valuation in Deep Tech: How to Price What Doesn’t Exist Yet — Part 1
How do you build a pre-revenue valuation in deep tech, where ARR doesn’t exist and the “market” still needs to be educated?
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Giulia Spano, PhD
Exits in Advanced Materials Startups
3 Case Studies on How Exits Were Strategically Engineered Behind the Scenes.
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Giulia Spano, PhD

Capital Movements

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💸 $405M Robot Brains; $463M EV Anodes; $275M GPU Credit; $313M Gene Therapy; $230M Corporate Security; $100M Nuclear for AI | Capital…
The Week’s State of Deep Tech Capital: who’s Raising, who’s Betting, and why.
 • 
Giulia Spano, PhD
💸 $65M Series A Rare-Earth Magnets; $20M Series A Analog IC Design; $1.6M Pre-Seed Autonomous Drones; €650K Pre-Seed Industrial AI & more …
The Week’s State of Deep Tech Capital: who’s Raising, who’s Betting, and why.
 • 
Giulia Spano, PhD
💸 $200M Growth for AI Materials; $8.8M Seed for In-Orbit Defense Vehicle; $20M Series A for Semiconductor; $6M Seed to Advance Grid-Edge…
The Week’s State of Deep Tech Capital: who’s Raising, who’s Betting, and why.
 • 
Giulia Spano, PhD
💸 $11M Seed Dual-Chem Batteries; €325M Debt for EV Infra; $100M Series B Cloud Racks; $18.7M Seed Copper Recovery; $8.5M Series A In-Fab…
The Week’s State of Deep Tech Capital: who’s Raising, who’s Betting, and why.
 • 
Giulia Spano, PhD

VC Guides

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28:55
Investing in Mining Tech: Scalable Models, Case Studies, And Due Diligence
From AI-Driven Discovery to Critical Mineral Supply Chains | Jason Holt, Partner @ Orion Industrial Ventures
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Nicola Marchese, MD
From STEM to Deep Tech VC
The Essential Guide for Scientists Entering Venture Capital | Chloë Payne, Principal at Ponderosa Ventures
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Nicola Marchese, MD
32:02
How to Invest in Robotics Startups: Insights and Tactics from a VC Perspective
Due Diligence, Insights, and Case Studies | Karthee Madasamy, Founder & Managing Partner at MFV Partners
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Nicola Marchese, MD
30:59
Winning the Deep Tech Scaling Bottleneck
Practical Tactics and Strategies to Support Industrial Startups at Scale | Phil Morle, Partner @ Main Sequence Ventures
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Nicola Marchese, MD
28:47
Dual-Use VC Investing
Due Diligence, Insights, and Case Studies | Sherman Williams, Managing Partner, and Forrest Underwood, Venture Partner, @ AIN Ventures
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Nicola Marchese, MD
23:54
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