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ISRU and Beyond: Venturing into the New Space Race | Deep Tech Catalyst

A chat with Taylor Sargent, Partner @ Industrious Ventures

Welcome to the 118th edition of Deep Tech Catalyst, the educational channel from The Scenarionist where science meets venture!

This week, we explore one of the most ambitious frontiers in Deep Tech: what it will take to build a sustained industrial presence beyond Earth, and why the economics of that future depend on learning to use resources where they are found.

I sat down with Taylor Sargent, Partner at Industrious Ventures, to unpack why the renewed race to the Moon is about much more than exploration, how investors should think about timing in frontier space markets, and what has to be built before in-situ resource utilization (ISRU) can move from scientific promise to commercial reality.

Key takeaways from the episode:

🌕 The Moon Is Becoming a Strategic Infrastructure Asset
The new lunar race is not just about getting there first. It is about building permanent infrastructure that can support exploration, manufacturing, and future space operations at scale.

🪨 In-Situ Resource Utilization Starts With Economics
If everything has to be brought from Earth, a lasting lunar presence becomes prohibitively expensive. Using local resources is not a futuristic add-on. It is one of the conditions that could make permanence possible.

🛰️ Lunar Infrastructure Will Be Built as a Stack
Mobility, power, communications, orbital logistics, and site preparation are not separate stories. They are interdependent layers of the same emerging system.

⏱️ In Frontier Markets, Timing Matters as Much as Vision
A company can be directionally right and still fail if the market arrives too slowly. In lunar infrastructure, the hardest question is not whether the opportunity could exist, but whether it is investable now.

📜 Policy Is Not External to the Market
In space, regulation is part of the business environment from day one. Founders cannot treat policy as an afterthought if they want to build companies that can actually operate and scale.



BEYOND THE CONVERSATION — STRATEGIC INSIGHTS FROM THE EPISODE

The Moon Is Back at the Center of Strategic Competition

Framing the context for this cutting-edge conversation requires starting with a basic question: why is the Moon at the center of strategic interest in 2026?

The current race to the Moon is often described in technological terms, or seen as a natural continuation of scientific ambition. But the underlying logic is more strategic than symbolic.

The earlier race was about getting there first. The current one is about building the foundations of a lasting presence.

The ambition is no longer limited to reaching the lunar surface, demonstrating technical superiority, and returning home. It is increasingly about creating permanent infrastructure that can support future operations beyond a single mission or a short sequence of missions.

That shift changes the meaning of the Moon itself. The Moon is not just a destination. It is an asset.

Its value lies in what it could enable if infrastructure can be established there reliably and economically, making future exploration and in-space operations easier, cheaper, and more scalable.

And this is where the strategic logic becomes even more interesting.

A useful way to think about it is that space access is not defined only by distance. It is defined by the energy required to move in and out of gravitational environments.

That is why the Moon can matter not only as a place to reach, but as a place to build from. In that sense, the Moon matters because once infrastructure exists there, it may become a more advantageous starting point for broader exploration.

If the long-term goal is to operate more effectively across the solar system, then the ability to launch, manufacture, or stage missions from the lunar surface could become highly consequential.

More importantly, getting from the lunar surface to low Earth orbit may one day be dramatically less demanding than launching from Earth’s surface into orbit, which is part of why long-term manufacturing and logistics scenarios on the Moon are strategically interesting in the first place.

Beyond exploration, toward infrastructure and industry

That possibility extends beyond exploration in the narrow sense. It also begins to shape how the Moon is viewed in relation to industrial and logistical capabilities in space.

If materials can one day be processed there, and if systems can eventually be built there, then the Moon could become part of a larger space economy rather than simply a place visited occasionally by state-led missions.

That is why the comparison with the 1960s is useful, but only up to a point.

The competitive instinct is familiar. The geopolitical logic is familiar. But the present ambition is broader and more operational.

The race is to establish the conditions for staying, building, and using the Moon as part of a much larger system of exploration and infrastructure.

Seen that way, the Moon race is the beginning of a different kind of strategic project, one in which infrastructure (and, particularly, atoms) matter more than first arrival.



In-Situ Resource Utilization Starts With a Simple Economic Reality

Once the strategic case for the Moon is clear, the next question becomes practical: how can a lasting presence there ever become economically viable?

This is where in-situ resource utilization enters the picture. The concept may sound futuristic, but the logic behind it is straightforward.

If the goal is to build and sustain operations on the Moon, it is not realistic to assume that every material, every piece of infrastructure, and every operational input can continue to come from Earth.

The cost of transporting mass to the lunar surface is simply too high for that model to scale.

To make the economics more concrete: putting a single kilogram on the lunar surface can cost anywhere from roughly $500,000 to $1.2 million. At that level, the economics of shipping everything from Earth become a structural constraint, not just a budgeting problem.

So, at its core, in-situ resource utilization would allow using the resources found in a given place to support activity in that same place, helping offset those massive cost constraints.

In the lunar context, that means understanding what materials exist on the Moon and determining whether they can be processed, refined, or transformed into useful inputs for power, mobility, construction, or life support.

The more a lunar presence depends entirely on launches from Earth, the more fragile and expensive it remains. The more local materials can be turned into usable resources, the more that dependence begins to fall.

That perspective ties back to what we have just discussed and changes the role of the Moon itself. It is no longer just a place to reach. It becomes a place whose own material environment may eventually support the systems being built there.

This is why the conversation framed ISRU as central to the long-term logic of lunar development.



Building the Lunar Infrastructure Stack, One Layer at a Time

One of the most useful ideas in the conversation is that “a lunar economy” will not emerge from one breakthrough technology alone. It will have to be built as a stack.

That matters because discussions about the Moon often drift toward a single dramatic image: a rover, a habitat, a mining system, a reactor, a launch vehicle.

But the real picture is more interdependent than that.

Nothing on the lunar surface becomes truly useful in isolation. Each capability depends on several others already being in place, or at least developing alongside it.

This is why the path forward looks less like one decisive invention and more like the gradual assembly of a layered operating system for the Moon.

Mobility and site preparation

At the surface level, mobility is one of the earliest and most visible requirements. If there is going to be any meaningful activity on the Moon, systems need to move across the terrain, inspect it, understand it, and prepare it for future use.

That is part of making the lunar environment legible and operable.

A rover, in this sense, is not only a vehicle. It is an enabling tool for prospecting, mapping, science, logistics, and eventually construction.

Before local resources can be used, there has to be a way to characterize what is actually there. Before infrastructure can be deployed, there has to be a way to understand terrain conditions and prepare sites.

That point becomes even more important when the environment itself creates operational problems.

The lunar surface is not passive. The regolith, the Moon’s fine surface dust, is fine, abrasive, and easily disturbed.

Landers do not simply arrive neatly onto a stable pad. Their descent affects the surrounding area, which means that even the act of landing creates infrastructure needs of its own.

This is a striking detail because it shows how early the logic of systems thinking begins. Before one can imagine large-scale manufacturing or sustained habitation, there are already questions of site preparation, landing safety, and surface management.

Put simply, some infrastructure has to come before everything else. That is why mobility and site preparation are among the first layers in the stack.

Power, communications, and logistics

Surface operations alone are not enough. A Moon-based system also depends on the layers around and above it. Getting to the Moon still requires launch systems that can reduce the cost of reaching orbit.

Operating in space requires logistics capabilities that can move assets, extend mission life, and support positioning in orbit. And once something is placed on or around the Moon, it has to be powered and connected.

Power is foundational here.

A permanent or semi-permanent presence cannot exist without a reliable energy source. Whether that ultimately comes from solar systems, nuclear systems, or some combination of both, the point is the same: nothing else in the stack functions without it.

The same is true for communications.

Because only one side of the Moon permanently faces Earth, any serious activity on the far side depends on communications infrastructure in orbit that can relay signals back and forth. That makes lunar communications satellites not a secondary capability, but part of the minimum architecture required to operate across the full lunar environment.

Those are only some of the layers involved. This makes the whole opportunity look less like a single market and more like a coordinated architecture.

Mobility, launch, orbital logistics, power, and communications are interlocking requirements. Each one increases the usefulness of the others. Each one lowers friction for whatever comes next.

And each one represents an infrastructure piece in a broader industrial buildout that will likely unfold step by step rather than all at once.

That is also why, as discussed in the conversation, it is difficult to imagine a single company simply building the whole thing. The number of technical dependencies is too large, and the amount of mass, capital, autonomy, and coordination required is too great.

Even with significant funding, the challenge is not just scale. It is integration across many capabilities that must all function together in a harsh and distant environment.

The math in the conversation makes that point especially interesting.

If delivery costs are on the order of $1 million per kilogram, then even a billion-dollar effort only gets something like 1,000 kilograms onto the lunar surface. It’s hard to build an autonomous industrial facility from scratch with economics like that.

So, the more realistic view is that lunar infrastructure will emerge through an ecosystem of companies and programs, each solving part of the stack while enabling the next layer to become viable.



Timing Will Matter as Much as Vision

One of the most important venture lessons I keep learning is that frontier markets are not judged only by technical feasibility. They are heavily judged by timing. ISRU fits that pattern perfectly.

A founder or an investor may be entirely right about the long-term direction of a market and still lose if that market takes too long to materialize. In that sense, being too early is not a softer version of being right. It is functionally the same as being wrong.

That is a hard truth, especially in areas as compelling as lunar infrastructure, where the strategic logic can be persuasive well before commercial readiness exists.

It is easier to see the destination. It is much harder to know whether the path to revenue and adoption is close enough for a company to survive the journey.

This is why understanding timing (and, as we’ll see later, the customer) becomes the central question here.

The challenge is not vision, but customer readiness

A market may eventually become large and important, but if there is no near-term customer, or if the customer exists only in principle rather than in budget, procurement, or programmatic commitment, then the business is exposed.

It may rest on a strong set of assumptions and still fail because the surrounding market arrives too slowly. That is particularly relevant in categories where the first customer is likely to be government.

Unlike mature commercial markets, these environments do not always produce immediate price signals, dense customer pipelines, or rapid product iteration through private demand.

The early market often depends on whether public institutions have made a real commitment.

For that reason, founders cannot rely on broad excitement about the sector. They need evidence that someone is prepared to buy, fund, or contract the capability in a way that creates a viable bridge from technology to business.

This is where demand signals become decisive.

The point is not that a founder must wait until the market is fully formed. If everyone waits until certainty arrives, many of the most important companies will never get built.

The point is that the company must be founded at a moment when there is enough signal to support the path from technical capability to customer traction.

That requires much more than belief in the technology itself.

It requires a close reading of where the customer is headed, what budgets are emerging, what procurement cycles are opening, and whether the surrounding ecosystem is beginning to align around real use cases.

That is the venture logic the conversation keeps returning to.

In lunar infrastructure, as in many Deep Tech sectors, the real test is not whether the market could exist. It is whether the company is being built at the moment when that market is becoming actionable.



In Early Space Markets, Founders Have to Build With Government in Mind

One of the most grounded points to emerge from the conversation is that the first real lunar economy is unlikely to begin as a balanced commercial marketplace. As discussed, it will begin with government as the anchor customer.

That is not a weakness in the thesis. It is part of the structure of the opportunity.

When a sector is this capital intensive, this technically demanding, and this early in its development, the initial customer is almost inevitably the public sector.

The reason is simple, governments are likely to be the only actors with the strategic mandate, the long time horizon, and the tolerance for early-stage uncertainty required to underwrite the first layers of infrastructure.

That has direct implications for how founders should think about the market.

A company building for lunar infrastructure cannot begin from the assumption that a broad private customer base already exists. In most cases, it does not.

There may be niches of commercial experimentation, and there may be individual commercial missions that validate parts of the stack, but the dominant buyer in the early years will still be public institutions and government-backed programs.

That distinction matters because it means the business case should be grounded in a market shaped by government priorities, government budgets, and government contracts.

Private capital moves when the market becomes legible

The deeper point is that government is not only buying products. It is helping define the market itself.

This is where institutions like NASA become economically significant. The public sector does not merely fund missions for scientific or symbolic reasons. It also de-risks categories that private capital cannot yet underwrite alone.

That pattern has already appeared elsewhere in space.

Low Earth orbit did not become a meaningful commercial environment in isolation. It became one through years of public investment, technical validation, and institutional support that gradually reduced uncertainty.

Once that happened, private companies were able to enter, expand, and build businesses in communications, imaging, logistics, and other categories.

The same staged logic now appears to be extending toward the Moon.

That is why public commitment matters. When government begins to outline a longer-term infrastructure strategy, allocate meaningful capital, and describe the systems it expects to need, it does more than support exploration.

It also gives founders, operators, and investors a clearer sense of where demand may begin to form and which capabilities could become relevant first.

That matters because private capital rarely moves at scale on vision alone. There may be strong conviction that the Moon has long-term economic value. There may be a growing belief that local resources could eventually support power, mobility, life support, and propulsion.

But larger-scale private investment usually depends on something more concrete than possibility. It depends on the market becoming clear enough that companies can start building for real customers against a more visible sequence of needs.

Regulation is part of the business

That leads to a second important point: in space, regulation is not a side issue. It is part of the operating environment from the very beginning.

This is worth emphasizing because space is often imagined as a frontier defined mainly by engineering difficulty. And of course the engineering is extreme.

But the market is being shaped continuously by licensing regimes, launch permissions, communications standards, international agreements, and government oversight.

In other words, space is not simply hard because physics is hard. It is also hard because the path to operating legally and commercially runs directly through policy.

That makes regulation a strategic variable, not just a compliance burden.

A founder entering this category has to understand that many of the most essential elements of a space business already depend on regulated access.

Communication is one obvious example.

A satellite or lunar system cannot simply decide to transmit data back to Earth on its own terms. It needs the right to use a portion of the electromagnetic spectrum, and that right is scarce, structured, and regulated.

Launch operations, similarly, do not happen through technical readiness alone. They require coordination with aviation authorities and other public agencies to ensure that the activity can occur safely and lawfully.

These are not edge conditions. They are core market conditions.

The same logic extends further as activity shifts from Earth orbit toward the Moon.

International frameworks are already beginning to shape how states and companies think about lunar use, access, and cooperation. Some of the relevant standards have been established. Many others are still emerging.

Founders should engage with policy early

That creates a market in which founders are not simply operating under fixed rules. In some cases, they are operating while the rules are still being written.

That can look like uncertainty, but it is also a form of strategic opportunity.

The conversation makes an important point here: if a founder is building in a space-related category, especially one tied to lunar infrastructure, it is not enough to focus only on product development and customer engagement in the narrow sense.

Those remain essential, of course. But alongside them, there has to be active engagement with government institutions and regulatory bodies, because policy decisions will influence whether the company can operate effectively, whether barriers are lowered or raised, and whether the emerging framework makes room for commercially viable activity.

That is why policy work should not be overlooked.

In a market like this, engaging with regulators is part of building the company. It is a way of helping shape the conditions under which both the company and the category itself will mature.

A founder who understands it can do something more powerful: build the product while also helping make the market more navigable.

To recap, public institutions are not only regulators. They are often customers, funders, infrastructure builders, and standard setters at the same time.

That is the larger lesson. Before the lunar economy becomes broadly commercial, it must first become sufficiently de-risked. And for companies trying to build into an environment as ambitious and unfinished as the new space economy, understanding that map early may become a meaningful competitive advantage.



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